KEGG   Mus musculus (house mouse): 15251
Entry
15251             CDS       T01002                                 
Symbol
Hif1a, HIF-1-alpha, HIF1-alpha, HIF1alpha, MOP1, bHLHe78
Name
(RefSeq) hypoxia inducible factor 1, alpha subunit
  KO
K08268  hypoxia-inducible factor 1 alpha
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04066  HIF-1 signaling pathway
mmu04137  Mitophagy - animal
mmu04140  Autophagy - animal
mmu04148  Efferocytosis
mmu04659  Th17 cell differentiation
mmu04919  Thyroid hormone signaling pathway
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05200  Pathways in cancer
mmu05205  Proteoglycans in cancer
mmu05208  Chemical carcinogenesis - reactive oxygen species
mmu05211  Renal cell carcinoma
mmu05230  Central carbon metabolism in cancer
mmu05231  Choline metabolism in cancer
mmu05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    15251 (Hif1a)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    15251 (Hif1a)
   04137 Mitophagy - animal
    15251 (Hif1a)
   04148 Efferocytosis
    15251 (Hif1a)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    15251 (Hif1a)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    15251 (Hif1a)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    15251 (Hif1a)
   05205 Proteoglycans in cancer
    15251 (Hif1a)
   05208 Chemical carcinogenesis - reactive oxygen species
    15251 (Hif1a)
   05230 Central carbon metabolism in cancer
    15251 (Hif1a)
   05231 Choline metabolism in cancer
    15251 (Hif1a)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    15251 (Hif1a)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    15251 (Hif1a)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    15251 (Hif1a)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:mmu03000]
    15251 (Hif1a)
Transcription factors [BR:mmu03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    15251 (Hif1a)
SSDB
Motif
Pfam: PAS_3 PAS_11 HIF-1a_CTAD PAS HIF-1 PAS_9 PAS_4 HLH
Other DBs
NCBI-GeneID: 15251
NCBI-ProteinID: NP_034561
MGI: 106918
Ensembl: ENSMUSG00000021109
UniProt: Q61221 Q3UCW2
Structure
Position
12:73948186..73994304
AA seq 836 aa
MEGAGGENEKKKMSSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGGLDSEDEMKAQMDCFYLKALDGFVMVLTDDGDMVYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGPVRKGKELNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTESV
LKPVESSDMKMTQLFTKVESEDTSCLFDKLKKEPDALTLLAPAAGDTIISLDFGSDDTET
EDQQLEDVPLYNDVMFPSSNEKLNINLAMSPLPSSETPKPLRSSADPALNQEVALKLESS
PESLGLSFTMPQIQDQPASPSDGSTRQSSPERLLQENVNTPNFSQPNSPSEYCFDVDSDM
VNVFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNS
PSPPSMSTVTGFQQTQLQKPTITATATTTATTDESKTETKDNKEDIKILIASPSSTQVPQ
ETTTAKASAYSGTHSRTASPDRAGKRVIEQTDKAHPRSLNLSATLNQRNTVPEEELNPKT
IASQNAQRKRKMEHDGSLFQAAGIGTLLQQPGDCAPTMSLSWKRVKGFISSEQNGTEQKT
IILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
NT seq 2511 nt   +upstreamnt  +downstreamnt
atggagggcgccggcggcgagaacgagaagaaaaagatgagttctgaacgtcgaaaagaa
aagtctagagatgcagcaagatctcggcgaagcaaagagtctgaagttttttatgagctt
gctcatcagttgccacttccccacaatgtgagctcacatcttgataaagcttctgttatg
aggctcaccatcagttatttacgtgtgagaaaacttctggatgccggtggtctagacagt
gaagatgagatgaaggcacagatggactgtttttatctgaaagccctagatggctttgtg
atggtgctaacagatgacggcgacatggtttacatttctgataacgtgaacaaatacatg
gggttaactcagtttgaactaactggacacagtgtgtttgattttactcatccatgtgac
catgaggaaatgagagaaatgcttacacacagaaatggcccagtgagaaaagggaaagaa
ctaaacacacagcggagcttttttctcagaatgaagtgcaccctaacaagccgggggagg
acgatgaacatcaagtcagcaacgtggaaggtgcttcactgcacgggccatattcatgtc
tatgataccaacagtaaccaacctcagtgtgggtacaagaaaccacccatgacgtgcttg
gtgctgatttgtgaacccattcctcatccgtcaaatattgaaattcctttagatagcaag
acatttctcagtcgacacagcctcgatatgaaattttcttactgtgatgaaagaattact
gagttgatgggttatgagccggaagaacttttgggccgctcaatttatgaatattatcat
gctttggattctgatcatctgaccaaaactcaccatgatatgtttactaaaggacaagtc
accacaggacagtacaggatgcttgccaaaagaggtggatatgtctgggttgaaactcaa
gcaactgtcatatataatacgaagaactcccagccacagtgcattgtgtgtgtgaattat
gttgtaagtggtattattcagcacgacttgattttctcccttcaacaaacagaatctgtg
ctcaaaccagttgaatcttcagatatgaagatgactcagctgttcaccaaagttgaatca
gaggatacaagctgcctttttgataagcttaagaaggagcctgatgctctcactctgctg
gctccagctgccggcgacaccatcatctctctggattttggcagcgatgacacagaaact
gaagatcaacaacttgaagatgttccattatataatgatgtaatgtttccctcttctaat
gaaaaattaaatataaacctggcaatgtctcctttaccttcatcggaaactccaaagcca
cttcgaagtagtgctgatcctgcactgaatcaagaggttgcattaaaattagaatcaagt
ccagagtcactgggactttcttttaccatgccccagattcaagatcagccagcaagtcct
tctgatggaagcactagacaaagttcacctgagagacttcttcaggaaaacgtaaacact
cctaacttttcccagcctaacagtcccagtgaatattgctttgatgtggatagcgatatg
gtcaatgtattcaagttggaactggtggaaaaactgtttgctgaagacacagaggcaaag
aatccattttcaactcaggacactgatttagatttggagatgctggctccctatatccca
atggatgatgatttccagttacgttcctttgatcagttgtcaccattagagagcaattct
ccaagccctccaagtatgagcacagttactgggttccagcagacccagttacagaaacct
accatcactgccactgccaccacaactgccaccactgatgaatcaaaaacagagacgaag
gacaataaagaagatattaaaatactgattgcatctccatcttctacccaagtacctcaa
gaaacgaccactgctaaggcatcagcatacagtggcactcacagtcggacagcctcacca
gacagagcaggaaagagagtcatagaacagacagacaaagctcatccaaggagccttaac
ctgtctgccactttgaatcaaagaaatactgttcctgaggaagaattaaacccaaagaca
atagcttcgcagaatgctcagaggaagcgaaaaatggaacatgatggctccctttttcaa
gcagcaggaattggaacattattgcagcaaccaggtgactgtgcacctactatgtcactt
tcctggaaacgagtgaaaggattcatatctagtgaacagaatggaacggagcaaaagact
attattttaataccctccgatttagcatgcagactgctggggcagtcaatggatgagagt
ggattaccacagctgaccagttacgattgtgaagttaatgctcccatacaaggcagcaga
aacctactgcagggtgaagaattactcagagctttggatcaagttaactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Genome (1)   
   KEGG GENOME (1)   
Gene (19)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (6)   
DNA sequence (36)   
   RefSeq(nuc) (6)   
   GenBank (15)   
   EMBL (15)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   Pfam (8)   
All databases (90)   

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